Bioengineering Human Myocardium on Native Extracellular Matrix.

ABSTRACT: RATIONALE:More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting heart transplantation in the United States. Donor organ shortage and allograft rejection remain major limitations with only ≈2500 hearts transplanted each year. As a theoretical alternative to allotransplantation, patient-derived bioartificial myocardium could provide functional support and ultimately impact the treatment of heart failure. OBJECTIVE:The objective of this study is to translate previous work to human scale and clinically relevant cells for the bioengineering of functional myocardial tissue based on the combination of human cardiac matrix and human induced pluripotent stem cell-derived cardiomyocytes. METHODS AND RESULTS:To provide a clinically relevant tissue scaff

SUBMITTER: Guyette JP 

PROVIDER: S-EPMC4740234 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature