Ontology highlight
ABSTRACT:
SUBMITTER: Kwon DH
PROVIDER: S-EPMC4740400 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160201
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity via either chemical inhibitor or genetic ablation enhances VC. HDAC1 protein, but not mRNA, is reduced in cell and animal calcification models and in human calcified coronary artery. Under calcificatio ...[more]