Relationship between digital information and thermodynamic stability in bacterial genomes.

ABSTRACT: Ever since the introduction of the Watson-Crick model, numerous efforts have been made to fully characterize the digital information content of the DNA. However, it became increasingly evident that variations of DNA configuration also provide an "analog" type of information related to the physicochemical properties of the DNA, such as thermodynamic stability and supercoiling. Hence, the parallel investigation of the digital information contained in the base sequence with associated analog parameters is very important for understanding the coding capacity of the DNA. In this paper, we represented analog information by its thermodynamic stability and compare it with digital information using Shannon and Gibbs entropy measures on the complete genome sequences of several bacteria, including

SUBMITTER: Nigatu D 

PROVIDER: S-EPMC4740571 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature