Ontology highlight
ABSTRACT:
SUBMITTER: Mitterer V
PROVIDER: S-EPMC4740875 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160202
Eukaryotic ribosomes assemble by association of ribosomal RNA with ribosomal proteins into nuclear precursor particles, which undergo a complex maturation pathway coordinated by non-ribosomal assembly factors. Here, we provide functional insights into how successive structural re-arrangements in ribosomal protein S3 promote maturation of the 40S ribosomal subunit. We show that S3 dimerizes and is imported into the nucleus with its N-domain in a rotated conformation and associated with the chaper ...[more]