Study of the Association of Mutant HBsAg Gene and Hodgkin and Non-Hodgkin Lymphoma.

ABSTRACT:

Background

Hepatitis B Virus (HBV) is responsible for chronic, acute, and fulminant hepatitis, which are prevalent worldwide. Chronic HBV may lead to cirrhosis and hepatocellular carcinoma. Several epidemiological studies have indicated that hepatitis B virus is involved in B-cell Hodgkin and Non-Hodgkin Lymphoma (NHL).

Objectives

The aim of this study was to evaluate the association between hepatitis B infection and Hodgkin and non-Hodgkin Lymphoma.

Materials and methods

Paraffin embedded of 41 block samples including 12 (29.26%) Hodgkin and 29 (70.73%) non-Hodgkin patients were collected. Next, DNA extraction was carried out for all the samples followed by HBV DNA detection by the nested polymerase chain reaction (PCR). The positive HBV DNA samples were sequenced, a

SUBMITTER: Makvandi K 

PROVIDER: S-EPMC4740896 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature