Ontology highlight
ABSTRACT:
SUBMITTER: Bago JR
PROVIDER: S-EPMC4740908 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Bagó Juli R JR Alfonso-Pecchio Adolfo A Okolie Onyi O Dumitru Raluca R Rinkenbaugh Amanda A Baldwin Albert S AS Miller C Ryan CR Magness Scott T ST Hingtgen Shawn D SD
Nature communications 20160202
Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for personalized cell therapy. Here we provide evidence that TD-derived induced neural stem cells (iNSCs) are an efficacious therapeutic strategy for brain cancer. We find that iNSCs genetically engineered with optical reporters and tumouricidal gene products retain the capacity to differentiate and induced apopt ...[more]