MiR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications.

ABSTRACT:

Background

Dysregulation of miRNAs that can act as tumor suppressors or oncogenes can result in tumorigenesis. Previously we demonstrated that miR-199b was significantly downregulated in acute myeloid leukemia (AML) and targets podocalyxin and discoidin domain receptor 1. Herein we investigated the functional role of miR-199b in AML and its prognostic implications.

Methods

Major approaches include transduction of hematopoietic stem cells and bone marrow transplantation, analyses of blood lineages, histone deacetylases (HDAC) inhibitors, and molecular and clinical data analyses of AML patients using The Cancer Genome Atlas (TCGA).

Results

We first examined the relative miR-199b expression in steady state hematopoiesis and showed CD33(+) myeloid progenitors had the high

SUBMITTER: Favreau AJ 

PROVIDER: S-EPMC4740997 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature