Renal sympathetic denervation using MR-guided high-intensity focused ultrasound in a porcine model.

ABSTRACT:

Background

Initial catheter-based renal sympathetic denervation (RSD) studies demonstrated promising results in showing a significant reduction of blood pressure, while recent data were less successful. As an alternative approach, the objective of this study was to evaluate the feasibility of using magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) to perform RSD in a porcine model.

Methods

An intravascular fiber optic temperature probe was used to confirm energy delivery during MRgHIFU. This technique was evaluated both in a vascular phantom and in a normotensive pig model. Five animals underwent unilateral RSD using MRgHIFU, and both safety and efficacy were assessed. MRI was used to evaluate the acoustic window, target sonications, monitor the near-fiel

SUBMITTER: Koopmann M 

PROVIDER: S-EPMC4741025 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature