Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC.

ABSTRACT:

Background and objectives

Sickle cell disease (SCD) is an inherited anemia that afflicts millions worldwide. Kidney disease is a major contributor to its morbidity and mortality. We examined contemporary and historical SCD populations to understand how renal disease behaved in hemoglobin SS (HbSS) compared with HbSC.

Design, setting, participants, & measurements

Kidney function was examined in the multicentered Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk-PHaSST) Trial (HbSS=463; HbSC=127; years 2007-2009) and historical comparator populations from the Cooperative Study of Sickle Cell Disease (CSSCD; HbSS=708) and the Multicenter Study of Hydroxyurea in Sickle Cell Disease (MSH; HbSS=299).

Results

In adults with SCD, eGFR w

SUBMITTER: Drawz P 

PROVIDER: S-EPMC4741034 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature