Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.

ABSTRACT:

Background and objectives

Diabetes is the leading cause of kidney failure in the United States, but early structural determinants of renal function loss in type 2 diabetes are poorly defined. We examined the association between morphometrically determined renal structural variables and loss of renal function in 111 American Indians with type 2 diabetes who volunteered for a research kidney biopsy at the end of a 6-year clinical trial designed to test the renoprotective efficacy of losartan versus placebo. Participants were subsequently followed in an observational study, in which annual measurements of GFR (iothalamate) initiated during the clinical trial were continued.

Design, setting, participants, & measurements

Renal function loss was defined as ≥40% loss of GFR from th

SUBMITTER: Fufaa GD 

PROVIDER: S-EPMC4741038 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature