Reconstruction of the insulin-like signalling pathway of Haemonchus contortus.

ABSTRACT:

Background

In the present study, we reconstructed the insulin/insulin-like growth factor 1 signalling (IIS) pathway for Haemonchus contortus, which is one of the most important eukaryotic pathogens of livestock worldwide and is related to the free-living nematode Caenorhabditis elegans.

Methods

We curated full-length open-reading frames from assembled transcripts, defined the complement of genes that encode proteins involved in this pathway and then investigated the transcription profiles of these genes for all key developmental stages of H. contortus.

Results

The core components of the IIS pathway are similar to their respective homologs in C. elegans. However, there is considerable variation in the numbers of isoforms between H. contortus and C. elegans and an absen

SUBMITTER: Mohandas N 

PROVIDER: S-EPMC4741068 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature