Ontology highlight
ABSTRACT:
SUBMITTER: Morrison G
PROVIDER: S-EPMC4741304 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Morrison Gillian G Scognamiglio Roberta R Trumpp Andreas A Smith Austin A
The EMBO journal 20151216 3
The molecular machinery that directs formation of definitive endoderm from pluripotent stem cells is not well understood. Wnt/β-catenin and Nodal signalling have been implicated, but the requirements for lineage specification remain incompletely defined. Here, we demonstrate a potent effect of inhibiting glycogen synthase kinase 3 (GSK3) on definitive endoderm production. We find that downstream of GSK3 inhibition, elevated cMyc and β-catenin act in parallel to reduce transcription and DNA bindi ...[more]