Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.

ABSTRACT:

Background

Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001.

Methods

Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillanc

SUBMITTER: Hofstra LM 

PROVIDER: S-EPMC4741360 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature