CRC-113 gene expression signature for predicting prognosis in patients with colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is the third leading cause of global cancer mortality. Recent studies have proposed several gene signatures to predict CRC prognosis, but none of those have proven reliable for predicting prognosis in clinical practice yet due to poor reproducibility and molecular heterogeneity. Here, we have established a prognostic signature of 113 probe sets (CRC-113) that include potential biomarkers and reflect the biological and clinical characteristics. Robustness and accuracy were significantly validated in external data sets from 19 centers in five countries. In multivariate analysis, CRC-113 gene signature showed a stronger prognostic value for survival and disease recurrence in CRC patients than current clinicopathological risk factors and molecular alterations. We also d

SUBMITTER: Nguyen MN 

PROVIDER: S-EPMC4741632 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature