Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology.

ABSTRACT: Tumor sequencing has revolutionized oncology, allowing for detailed interrogation of the molecular underpinnings of cancer at an individual level. With this additional insight, it is increasingly apparent that not only do tumors vary within a sample (tumor heterogeneity), but also that each patient's individual tumor is a constellation of unique molecular aberrations that will require an equally unique personalized therapeutic regimen. We report here the results of 439 patients who underwent Clinical Laboratory Improvement Amendment (CLIA)-certified next generation sequencing (NGS) across histologies. Among these patients, 98.4% had a unique molecular profile, and aside from three primary brain tumor patients with a single genetic lesion (IDH1 R132H), no two patients within a given histolo

SUBMITTER: Patel SP 

PROVIDER: S-EPMC4741715 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature