MiR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity.

ABSTRACT: Exosomes (EVs) have relevance in cell-to-cell communication carrying pro-tumorigenic factors that participate in oncogenesis and drug resistance and are proposed to have potential as self-delivery systems. Advancing on our studies of EVs in triple-negative breast cancer, here we more comprehensively analysed isogenic cell line variants and their EV populations, tissues cell line variants and their EV populations, as well as breast tumour and normal tissues. Profiling 384 miRNAs showed EV miRNA content to be highly representative of their cells of origin. miRNAs most substantially down-regulated in aggressive cells and their EVs originated from 14q32. Analysis of miR-134, the most substantially down-regulated miRNA, supported its clinical relevance in breast tumours compared to matched norm

SUBMITTER: O'Brien K 

PROVIDER: S-EPMC4741729 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature