Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.

ABSTRACT: Tumor-initiating cells constitute a population within a tumor mass that shares properties with normal stem cells and is considered responsible for therapy failure in many cancers. We have previously demonstrated that knockdown of the nuclear envelope component Lamin A/C in human neuroblastoma cells inhibits retinoic acid-mediated differentiation and results in a more aggressive phenotype. In addition, Lamin A/C is often lost in advanced tumors and changes in the nuclear envelope composition occur during tumor progression. Based on our previous data and considering that Lamin A/C is expressed in differentiated tissues, we hypothesize that the lack of Lamin A/C could predispose cells toward a stem-like phenotype, thus influencing the development of tumor-initiating cells in neuroblastoma. Th

SUBMITTER: Nardella M 

PROVIDER: S-EPMC4741732 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature