Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.

ABSTRACT: The relevance of the intrinsic subtypes for clinical management of metastatic breast cancer is not comprehensively established. We aimed to evaluate the prevalence and prognostic significance of drifts in tumor molecular subtypes during breast cancer progression. A well-annotated cohort of 304 women with advanced breast cancer was studied. Tissue microarrays of primary tumors and synchronous lymph node metastases were constructed. Conventional biomarkers were centrally assessed and molecular subtypes were assigned following the 2013 St Gallen guidelines. Fine-needle aspirates of asynchronous metastases were transcriptionally profiled and subtyped using PAM50. Discordant expression of individual biomarkers and molecular subtypes was observed during tumor progression. Primary luminal-like tu

SUBMITTER: Kimbung S 

PROVIDER: S-EPMC4741767 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature