Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity.

ABSTRACT: Senescent cells secrete several molecules that help to prevent the progression of cancer. However, cancer cells can also misuse these secreted elements to survive and grow. Since the molecular and functional bases of these different elements remain poorly understood, we analyzed the effect of senescent mesenchymal stromal cell (MSC) secretome on the biology of ARH-77 myeloma cells. In addition to differentiating in mesodermal derivatives, MSCs have sustained interest among researchers by supporting hematopoiesis, contributing to tissue homeostasis, and modulating inflammatory response, all activities accomplished primarily by the secretion of cytokines and growth factors. Moreover, senescence profoundly affects the composition of MSC secretome. In this study, we induced MSC senescence by o

SUBMITTER: Ozcan S 

PROVIDER: S-EPMC4741840 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature