Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.

ABSTRACT: Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide. Hence, it has been ranked by the World Health Organization as a top disorder of morbidity and lost productivity. Previous neuropathological studies have revealed a series of alterations in the brains of patients with bipolar disorder or animal models, such as reduced glial cell number in the prefrontal cortex of patients, upregulated activities of the protein kinase A and C pathways and changes in neurotransmission. However, the roles and causation of these changes in bipolar disorder have been too complex to exactly determine the pathology of the disease. Furthermore, although some patients show remarkable improv

SUBMITTER: Mertens J 

PROVIDER: S-EPMC4742055 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature