Network Scale Modeling of Lymph Transport and Its Effective Pumping Parameters.

ABSTRACT: The lymphatic system is an open-ended network of vessels that run in parallel to the blood circulation system. These vessels are present in almost all of the tissues of the body to remove excess fluid. Similar to blood vessels, lymphatic vessels are found in branched arrangements. Due to the complexity of experiments on lymphatic networks and the difficulty to control the important functional parameters in these setups, computational modeling becomes an effective and essential means of understanding lymphatic network pumping dynamics. Here we aimed to determine the effect of pumping coordination in branched network structures on the regulation of lymph flow. Lymphatic vessel networks were created by building upon our previous lumped-parameter model of lymphangions in series. In our network

SUBMITTER: Jamalian S 

PROVIDER: S-EPMC4742072 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature