URGCP promotes non-small cell lung cancer invasiveness by activating the NF-κB-MMP-9 pathway.

ABSTRACT: Invasion and metastasis are main traits of tumor progression and responsible for the poor prognosis of advanced non-small cell lung cancer (NSCLC). The molecular mechanisms underlying the malignant behaviors of NSCLC remain incompletely understood. The present study demonstrate that up-regulator of cell proliferation (URGCP), a recently identified tumor-promoting gene found in several tumor types, is markedly overexpressed in human NSCLC cell lines and clinical NSCLC samples. URGCP upregulation correlates significantly with the progression and poor prognosis of this disease. In vitro and in vivo studies demonstrate that increasing URGCP expression accelerates invasion, migration, and distant metastasis of NSCLC cells whereas downregulating URGCP suppresses these malignant traits. Notably,

SUBMITTER: Cai J 

PROVIDER: S-EPMC4742191 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature