DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells.

ABSTRACT: Defining new therapeutic strategies to overcome therapy resistance due to tumor heterogeneity in colon cancer is challenging. One option is to explore the molecular profile of aggressive disseminating tumor cells. The cytoskeleton-associated Death-associated protein kinase (DAPK) is involved in the cross talk between tumor and immune cells at the invasion front of colorectal cancer. Here dedifferentiated tumor cells histologically defined as tumor budding are associated with a high risk of metastasis and poor prognosis. Analyzing samples from 144 colorectal cancer patients we investigated immunhistochemical DAPK expression in different tumor regions such as center, invasion front, and buds. Functional consequences for tumor aggressiveness were studied in a panel of colon tumor cell lines u

SUBMITTER: Ivanovska J 

PROVIDER: S-EPMC4742210 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature