A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.

ABSTRACT:

Background

Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants near the LRRK2 gene have been associated with leprosy in some but not in other studies. We hypothesized that LRRK2 was a T1R susceptibility gene and that inconsistent association results might reflect different proportions of patients with T1R in the different sample settings. Hence, we evaluated the association of LRRK2 variants with T1R susceptibility.

Methodology

An association scan of the LRRK2 locus was performed using 156 single-nucleotide polymorphisms (SNPs). Evidence of a

SUBMITTER: Fava VM 

PROVIDER: S-EPMC4742274 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature