Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis.

ABSTRACT:

Background

The widespread use of cannabis, the increasing legalization of "medical" cannabis, the increasing potency of cannabis and the growing recreational use of synthetic cannabinoid 1 receptor (CB1R) full agonists underscores the importance of elucidating the effects of cannabinoids on the CB1R system. Exposure to cannabinoids is known to result in CB1R downregulation. However, the precise time course of changes in CB1R availability in cannabis dependent subjects (CDs) following short and intermediate term abstinence has not been determined.

Methods

Using High Resolution Research Tomography (HRRT) and [¹¹C]OMAR, CB1R availability as indexed by the volume of distribution (V_T) [¹¹C]OMAR was measured in male CDs (n=11) and matched he

SUBMITTER: D'Souza DC 

PROVIDER: S-EPMC4742341 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature