Relation between the level of lymph node metastasis and survival in locally advanced head and neck squamous cell carcinoma.

ABSTRACT:

Background

The current head and neck squamous cell carcinoma (HNSCC) staging system may not capture the full prognostic implications of regional lymph node involvement. This study investigated the impact of the level of lymph node metastasis (LNM) on survival.

Methods

The Surveillance, Epidemiology, and End Results registry was queried for oral cavity (OC), oropharynx (OP), larynx (LAR), and hypopharynx (HP) HNSCC. A multivariate Cox proportional hazards model was used to evaluate whether the level of LNM was an independent prognostic factor. Site-specific recursive-partitioning analysis was performed to classify patients into different risk groups.

Results

In all, 14,499 patients, including OC (n = 2463), OP (n = 8567), LAR (n = 2332), and HP patients (n = 1137), wer

SUBMITTER: Xing Y 

PROVIDER: S-EPMC4742373 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature