Ambient air pollution, lung function, and airway responsiveness in asthmatic children.

ABSTRACT:

Background

Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthmatic patients are lacking.

Objective

We sought to investigate pollution effects in a longitudinal asthma study and effect modification by controller medications.

Methods

We examined associations of lung function and methacholine responsiveness (PC20) with ozone, carbon monoxide (CO), nitrogen dioxide, and sulfur dioxide concentrations in 1003 asthmatic children participating in a 4-year clinical trial. We further investigated whether budesonide and nedocromil modified pollution effects. Daily pollutant concentrations were linked to ZIP/postal code of residence. Linear mixed models tested associations of within-subje

SUBMITTER: Ierodiakonou D 

PROVIDER: S-EPMC4742428 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature