Respiratory mechanics and lung stress/strain in children with acute respiratory distress syndrome.

ABSTRACT:

Background

In sedated and paralyzed children with acute respiratory failure, the compliance of respiratory system and functional residual capacity were significantly reduced compared with healthy subjects. However, no major studies in children with ARDS have investigated the role of different levels of PEEP and tidal volume on the partitioned respiratory mechanic (lung and chest wall), stress (transpulmonary pressure) and strain (inflated volume above the functional residual capacity).

Methods

The end-expiratory lung volume was measured using a simplified closed circuit helium dilution method. During an inspiratory and expiratory pause, the airway and esophageal pressure were measured. Transpulmonary pressure was computed as the difference between airway and esophageal press

SUBMITTER: Chiumello D 

PROVIDER: S-EPMC4742456 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature