Identification of differentially expressed signatures of long non-coding RNAs associated with different metastatic potentials in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is known for its lymph node metastasis and outstanding morbidity and mortality. Thus, improvement in the current knowledge regarding the molecular mechanism of GC is urgently needed to discover novel biomarkers involved in its progression and prognosis. Several long, non-coding RNAs (lncRNAs) play important roles in gastric tumorigenesis and metastasis. However, the signature of lncRNA-associated metastasis in GC is not fully clarified.

Methods

We determined the lncRNA and mRNA expression profiles correlating to GC with or without lymph node-metastasis based on microarray analysis. Twelve differentially expressed lncRNAs and six differentially expressed mRNAs were validated by real-time quantitative reverse transcription-polymerase chain reacti

SUBMITTER: Song W 

PROVIDER: S-EPMC4742487 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature