Characterization of the aodA, dnmA, mnSOD and pimA genes in Aspergillus nidulans.

ABSTRACT: Mitochondria play key roles in cellular energy generation and lifespan of most eukaryotes. To understand the functions of four nuclear-encoded genes predicted to be related to the maintenance of mitochondrial morphology and function in Aspergillus nidulans, systematic characterization was carried out. The deletion and overexpression mutants of aodA, dnmA, mnSOD and pimA encoding alternative oxidase, dynamin related protein, manganese superoxide dismutase and Lon protease, respectively, were generated and examined for their growth, stress tolerances, respiration, autolysis, cell death, sterigmatocystin production, hyphal morphology and size, and mitochondrial superoxide production as well as development. Overall, genetic manipulation of these genes had less effect on cellular physiology and

SUBMITTER: Leiter E 

PROVIDER: S-EPMC4742808 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature