Ontology highlight
ABSTRACT:
SUBMITTER: Kristjansson RP
PROVIDER: S-EPMC4742860 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160203
Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK and LDH, 28.3 million sequence variants identified through whole-genome sequencing of 2,636 Icelanders were imputed into 63,159 and 98,585 people with CK and LDH measurements, respectively. Here we describe 13 variants associating with serum CK and 16 with LDH levels, including four that associate with both. Among those, 15 are non-synonymo ...[more]