Bone loss and vitamin D deficiency in children undergoing hematopoietic cell transplantation.

ABSTRACT:

Background

Hematopoietic cell transplantation (HCT) may be detrimental to bone health and vitamin D status in children.

Procedure

We conducted a prospective, multicenter cohort study to identify changes in bone health markers during the first 100 days after allogeneic HCT in 26 children. Bone mineral density (BMD), bone mineral content (BMC), and serum 25-hydroxyvitamin D (25OHD) concentrations were measured at baseline, 30 days, and 100 days after HCT.

Results

Mean (SD) BMD and BMC Z-scores (-0.48 ± 1.09 and -0.98 ± 1.26, respectively) were normal at baseline. Repeated-measures analysis revealed significant declines in BMD and BMC Z-scores over the 100 day study period, when adjusted for age, sex, Tanner stage, lean mass, fat mass, resting energy expenditure, total e

SUBMITTER: Bechard LJ 

PROVIDER: S-EPMC4743025 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature