Blunted neural responses to reward in remitted major depression: A high-density event-related potential study.

ABSTRACT:

Background

Major depressive disorder (MDD) is a highly recurrent condition, and improving our understanding of the abnormalities that persist in remitted MDD (rMDD) may provide insight into mechanisms that contribute to relapse. MDD has been characterized by reward learning deficits linked to dysfunction in frontostriatal regions. Although initial behavioral evidence of reward learning deficits in rMDD has recently emerged, it is unclear whether these reflect impairments in neural reward processing that persist into remission.

Methods

We examined behavioral reward learning and 128-channel event-related potentials (ERP) during a well-validated probabilistic reward task in 26 rMDD individuals and 34 never-depressed controls. Temporo-spatial principal components analysis (PCA)

SUBMITTER: Whitton AE 

PROVIDER: S-EPMC4743048 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature