Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study.

ABSTRACT:

Background

Antiplatelet therapy may attenuate the undesirable effects of platelets on the inflammatory cascades in critical illness. The objective of this study was to evaluate the association between aspirin therapy during intensive care unit (ICU) stay and all-cause mortality.

Methods

This was a nested cohort study within two randomized controlled trials in which all enrolled patients (N = 763) were grouped according to aspirin intake during ICU stay. The primary endpoints were all-cause ICU mortality and hospital mortality. Secondary endpoints included the development of severe sepsis during the ICU stay, ICU and hospital length of stay and the duration of mechanical ventilation. Propensity score was used to adjust for clinically and statistically relevant variables.

R

SUBMITTER: Al Harbi SA 

PROVIDER: S-EPMC4743206 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature