No Association of ApoE Genotype with Risk of Prostate Cancer: A Nested Case-Control Study.

ABSTRACT:

Background

Previous studies found that low total cholesterol level was associated with a lower risk of high-grade prostate cancer. Apolipoprotein E (ApoE) isoform is associated with total cholesterol level. The aim of this study was to explore associations of ApoE isoforms with prostate cancer risk.

Methods

We assessed ApoE genotypes and risk of prostate cancer in a prospective case-control study nested among men who provided a blood sample in 1993-95 within the Health Professionals Follow-up Study. We identified 1,169 incident cases of prostate cancer and 1,233 controls in follow-up through 2004. Associations of ApoE isoform and prostate cancer incidence were evaluated by logistic regression models.

Results

We found no statistically significant associations of ApoE v

SUBMITTER: Liu H 

PROVIDER: S-EPMC4743244 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature