Enhanceosome transcription factors preferentially dimerize with high mobility group proteins.

ABSTRACT:

Background

The enhanceosome is an enhancer located upstream of the human interferon β gene, bound by transcription factor (TF) complex of extremely rigid structure. Within these rigid constraints, even a slight change of distances between transcription factor binding sites (TFBS) results in loss of functionality of the enhanceosome. We hypothesized that smaller subunits of the enhanceosome may entail TF complex formation in other regulatory regions.

Results

In order to verify this hypothesis we systematically searched for dimerization preferences of the TFs that have TFBS in the enhanceosome. For this we utilized our recently developed tool, TACO. We performed this computational experiment in a cell-type-specific manner by utilizing cell-type-specific DNase-seq data for 105

SUBMITTER: Jankowski A 

PROVIDER: S-EPMC4743414 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature