Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men.

ABSTRACT:

Background/aim

Several studies have revealed an association between single nucleotide polymorphisms (SNPs) in the VDR gene and prostate cancer (PCa) risk in European and Asian populations. To investigate whether VDR SNPs are associated with PCa risk in African-American (AA) men, nine VDR SNPs were analyzed in a case-control study.

Materials and methods

Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

Results

rs731236 and rs7975232 were significantly associated with PCa risk (p<0.05). In the analysis of clinical phenotypes, rs731236, rs1544410 and rs3782905 were strongly associated with high PSA level (p<0.05), whereas rs1544410 and rs2239185 showed a statistically significant association with high Gleason score (p

SUBMITTER: Jingwi EY 

PROVIDER: S-EPMC4743656 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature