High prevalence of PI resistance in patients failing second-line ART in Vietnam.

ABSTRACT:

Background

There are limited data from resource-limited settings on antiretroviral resistance mutations that develop in patients failing second-line PI ART.

Methods

We performed a cross-sectional virological assessment of adults on second-line ART for ≥6 months between November 2006 and December 2011, followed by a prospective follow-up over 2 years of patients with virological failure (VF) at the Hospital for Tropical Diseases, Vietnam. VF was defined as HIV RNA concentrations ≥1000 copies/mL. Resistance mutations were identified by population sequencing of the pol gene and interpreted using the 2014 IAS-USA mutation list and the Stanford algorithm. Logistic regression modelling was performed to identify predictors of VF.

Results

Two hundred and thirty-one patients w

SUBMITTER: Thao VP 

PROVIDER: S-EPMC4743698 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature