Association study of androgen signaling pathway genes in polycystic ovary syndrome.

ABSTRACT:

Objective

To evaluate genes involved in androgen receptor (AR) signaling as candidate genes for polycystic ovary syndrome (PCOS).

Design

Two groups of women with PCOS and control women (discovery and replication cohorts), were genotyped for single-nucleotide polymorphisms (SNPs) in eight genes for AR chaperones and co-chaperones: HSPA1A, HSPA8, ST13, STIP1, PTGES3, FKBP4, BAG1, and STUB1. Single-nucleotide polymorphisms were tested for association with PCOS status and with androgenic and metabolic parameters.

Setting

Tertiary referral center.

Patient(s)

Discovery cohort: 354 women with PCOS and 161 control women. Replication cohort: 397 women with PCOS and 306 control women.

Intervention(s)

Phenotypic and genotypic assessment.

Main outcome measure(s)<

SUBMITTER: Ketefian A 

PROVIDER: S-EPMC4744098 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature