Cell Fate Specification Based on Tristability in the Inner Cell Mass of Mouse Blastocysts.

ABSTRACT: During development, interactions between transcription factors control the specification of different cell fates. The regulatory networks of genetic interactions often exhibit multiple stable steady states; such multistability provides a common dynamical basis for differentiation. During early murine embryogenesis, cells from the inner cell mass (ICM) can be specified in epiblast (Epi) or primitive endoderm (PrE). Besides the intracellular gene regulatory network, specification is also controlled by intercellular interactions involving Erk signaling through extracellular Fgf4. We previously proposed a model that describes the gene regulatory network and its interaction with Erk signaling in ICM cells. The model displays tristability in a range of Fgf4 concentrations and accounts for the se

SUBMITTER: De Mot L 

PROVIDER: S-EPMC4744165 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature