Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer.

ABSTRACT:

Background

Drug resistance in breast cancer is the major obstacle to effective treatment with chemotherapy. While upregulation of multidrug resistance genes is an important component of drug resistance mechanisms in vitro, their clinical relevance remains to be determined. Therefore, identifying pathways that could be targeted in the clinic to eliminate anthracycline-resistant breast cancer remains a major challenge.

Methods

We generated paired native and epirubicin-resistant MDA-MB-231, MCF7, SKBR3 and ZR-75-1 epirubicin-resistant breast cancer cell lines to identify pathways contributing to anthracycline resistance. Native cell lines were exposed to increasing concentrations of epirubicin until resistant cells were generated. To identify mechanisms driving epirubicin resis

SUBMITTER: Braunstein M 

PROVIDER: S-EPMC4744406 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature