Tumour regression in the randomized Stockholm III Trial of radiotherapy regimens for rectal cancer.

ABSTRACT:

Background

The Stockholm III Trial randomized patients with primary operable rectal cancers to either short-course radiotherapy (RT) with immediate surgery (SRT), short-course RT with surgery delayed 4-8 weeks (SRT-delay) or long-course RT with surgery delayed 4-8 weeks. This preplanned interim analysis examined the pathological outcome of delaying surgery.

Methods

Patients randomized to the SRT and SRT-delay arms in the Stockholm III Trial between October 1998 and November 2010 were included, and data were collected in a prospective register. Additional data regarding tumour regression grade, according to Dworak, and circumferential margin were obtained by reassessment of histopathological slides.

Results

A total of 462 of 545 randomized patients had specimens availa

SUBMITTER: Pettersson D 

PROVIDER: S-EPMC4744683 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature