Evolving transcriptomic fingerprint based on genome-wide data as prognostic tools in prostate cancer.

ABSTRACT:

Background information

Prostate cancer (PCa) is a common disease but only a small subset of patients are at risk of developing metastasis and lethal disease, and identifying which patients will progress is challenging because of the heterogeneity underlying tumour progression. Understanding this heterogeneity at the molecular level and the resulting clinical impact is a critical step necessary for risk stratification. Defining genomic fingerprint elucidates molecular variation and may improve PCa risk stratification, providing more accurate prognostic information of tumour aggressiveness (or lethality) for prognostic biomarker development. Therefore, we explored transcriptomic differences between patients with indolent disease outcome and patients who developed metastasis post-radi

SUBMITTER: Alshalalfa M 

PROVIDER: S-EPMC4744779 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature