Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.

ABSTRACT: The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge.

SUBMITTER: Hesse S 

PROVIDER: S-EPMC4744919 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature