A randomized trial of ethyl lauroyl arginate-containing mouthrinse in the control of gingivitis.

ABSTRACT:

Aim

This 4-week, single-centre, randomized, examiner-blind, controlled study investigated the efficacy and safety of 0.15% ethyl lauroyl arginate (LAE)-containing mouthrinse in adults with mild-to-moderate gingivitis.

Material and methods

Subjects were randomized to use 0.15% LAE-containing mouthrinse or 5% hydroalcohol-negative control twice daily after brushing with standard fluoride toothpaste. Plaque, gingivitis and bleeding were assessed at baseline and Weeks 2 and 4. The oral microflora was analysed at baseline and Week 4.

Results

Eighty-seven subjects were randomized to treatment. The 0.15% LAE-containing mouthrinse was associated with statistically significantly (p < 0.001) greater reductions in mean plaque and gingivitis scores versus the negative control at

SUBMITTER: Gallob JT 

PROVIDER: S-EPMC4744955 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature