Rapid 3D Extrusion of Synthetic Tumor Microenvironments.

ABSTRACT: The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

SUBMITTER: Grolman JM 

PROVIDER: S-EPMC4745120 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature