Resistance related metabolic pathways for drug target identification in Mycobacterium tuberculosis.

ABSTRACT:

Background

Increasing resistance to anti-tuberculosis drugs has driven the need for developing new drugs. Resources such as the tropical disease research (TDR) target database and AssessDrugTarget can help to prioritize putative drug targets. Hower, these resources do not necessarily map to metabolic pathways and the targets are not involved in dormancy. In this study, we specifically identify drug resistance pathways to allow known drug resistant mutations in one target to be offset by inhibiting another enzyme of the same metabolic pathway. One of the putative targets, Rv1712, was analysed by modelling its three dimensional structure and docking potential inhibitors.

Results

We mapped 18 TB drug resistance gene products to 15 metabolic pathways critical for mycobacterial g

SUBMITTER: Cloete R 

PROVIDER: S-EPMC4745158 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature