Bio Prospecting of Marine-derived Streptomyces spectabilis VITJS10 and Exploring its Cytotoxicity Against Human Liver Cancer Cell Lines.

ABSTRACT:

Background

Recently, numerous pathogens have developed resistance due to the indiscriminate use of commercial therapeutic drugs.

Objective

The main aim of the study was to evaluate the bioactive potential of the Streptomyces spectabilis VITJS10 crude extract.

Materials and methods

The S. spectabilis VITJS10 ethyl acetate extract was tested for antibacterial, antioxidant, and cytotoxic properties. Genotypic characterization was done using 16S r-DNA partial gene amplification and sequencing. The authenticity of the crude chemical constitutes were determined by gas chromatography-mass spectrometry (GC-MS).

Results

The antibacterial potential revealed the effective activity against Shigellaflexneri (MTCC No: 1457) (22 mm), Salmonella typhi (MTCC No: 1167) (23 mm),

SUBMITTER: Selvakumar JN 

PROVIDER: S-EPMC4745219 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature