Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort.

ABSTRACT:

Background

Contradictory information exists regarding the influence of CYP2D6 polymorphisms on adverse drug reactions (ADRs) (extrapyramidal symptoms (EPS) and weight gain) related to risperidone treatment. This prompted us to evaluate the influence of CYP2D6 genetic variation in a cohort of South African patients who presented with marked movement disorders and/or weight gain while on risperidone treatment.

Methods

Patients who were experiencing marked risperidone ADRs were recruited from Weskoppies Public Psychiatric Hospital. As poor or intermediate metabolism was expected, comprehensive CYP2D6 sequence variations were evaluated using XL-PCR + Sequencing.

Results

No statistically significant association was found between CYP2D6 poor metabolism and risperidone ADRs.

SUBMITTER: Dodgen TM 

PROVIDER: S-EPMC4745369 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature