MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis.

ABSTRACT: Host-microbial interactions within the mammalian intestines must be properly regulated in order to promote host health and limit disease. Because the microbiota provide constant immunological signals to intestinal tissues, a variety of regulatory mechanisms have evolved to ensure proper immune responses to maintain homeostasis. However, many of the genes that comprise these regulatory pathways, including immune-modulating microRNAs (miRNAs), have not yet been identified or studied in the context of intestinal homeostasis. Here, we investigated the role of microRNA-146a (miR-146a) in regulating intestinal immunity and barrier function and found that this miRNA is expressed in a variety of gut tissues in adult mice. By comparing intestinal gene expression in WT and miR-146a-/- mice, we demon

SUBMITTER: Runtsch MC 

PROVIDER: S-EPMC4745677 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature